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The Swedish study "came right in line with other data that was emerging … which actually improves confidence that there's an association," Dr. Cynthia Sears, senior author of the U.K. study, who was not involved in the newest research, told Live Science. It's important to note that these studies only identify a correlation; they don't show that antibiotics directly cause the subsequent colon cancer, said Sears, who is a professor of medicine and oncology at the Johns Hopkins University School of Medicine and a professor of molecular microbiology and immunology at the Bloomberg School of Public Health. That said, there are theories as to how the drugs may make the proximal gut more vulnerable to cancer growth. "Our thinking is that you're disrupting the balance of the microbiota," and this may allow infectious bugs like Escherichia coli and Klebsiella pneumoniae to gain prominence where they'd usually be outcompeted by other microbes, Sears said. This in turn may ramp up inflammation in the colon, generating reactive chemicals that could damage DNA and generate tumors. In addition, the inner lining of the intestine may then become more permeable, allowing bacteria to infiltrate the colon walls and join together in slimy structures called biofilms. Studies suggest that almost all proximal colon cancers — nearly 90% — are associated with such biofilms, Sears said. The proximal colon may be particularly vulnerable to these changes because it endures the greatest spillover of antibiotic drugs from the small intestine, Sears said. Then, as the drugs move through the colon, their molecules steadily break down. That said, these potential mechanisms still need to be studied further, but for now, the new study strengthens the case that some link exists between antibiotics and colon cancer, she said. The new study used data from the Swedish Colorectal Cancer Registry to identify tens of thousands of colorectal cancer patients who had been diagnosed between 2010 and 2016. Data from the Swedish Prescribed Drug Register allowed the team to track these patients' antibiotic use between 2005 to 2016, to see if any patterns emerged. They also compared the cancer patients to more than 200,000 cancer-free people from the wider Swedish population. Related: 7 odd things that raise your risk of cancer (and 1 that doesn't) While the team uncovered a clear link between antibiotics use and cancer in the ascending colon, they found no such link to cancers in any part of the distal colon or rectum.   The team wanted to pin down why the drugs might drive cancer in the proximal colon.

https://www.livescience.com/colon-cancer-antibiotic-use-link.html

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“You may decide to ignore strong advice today from many of the top medics in the country. But please don’t dismiss it,” said Mr Reid said on Twitter. “If, as an adult, you decide not to be vaccinated, you do put yourself and others at much higher risk. We won’t leave anyone behind and it’s never too late.” The walk-in clinics are predominantly for the first dose of the mRNA vaccines – Pfizer-BioNTech and Moderna – while some are offering second doses. There must be a gap of at least 21 days after your first dose before you can receive your second. Covid-19 ‘perfect storm’ for teenage eating disorders, figures show #VaccinesWork . We have seen extraordinary uptake of vaccination in Ireland, and this is making us safer, but we need to give the vaccines time to work. The message: get your vaccine, get your second dose, and wait the 7-14 days they need to build your immunity. 1/7 pic.twitter.com/giFJ7G5OD6 — Professor Philip Nolan (@President_MU) August 21, 2021 If you have not registered for the vaccine online, you must bring your Personal Public Service number, Eircode, mobile phone number, email address and photo ID (passport, driving licence, Garda age card, school ID) to the walk-in centre. Parents or guardians of children aged 12 to 15 can register for them to receive the vaccine. Prof Philip Nolan , head of the National Public Health Emergency Team data modelling group, said there has been an “extraordinary uptake” of vaccination in Ireland “and this is making us safer, but we need to give the vaccines time to work”. Prof Nolan said more than 90 per cent of adults have had their first dose and in excess of 80 per cent are vaccinated fully . However, he said only about 75 per cent of adults are two weeks after their final dose and that “25 per cent of the adult population not yet fully vaccinated is enough for a large wave of disease. We are seeing continued growth in incidence, numbers in hospital and ICU. The cases are predominantly in young unvaccinated or partially vaccinated adults.” Prof Nolan said incidence of the virus should stabilise as the vaccination programme finishes and vaccines “take full effect through August and into September”. He added that “the trajectory between now and then is uncertain and requires we minimise the risks of any social contact”. State chief medical officer Tony Holohan warned on Friday that infection rates had not hit such highs since January. “This is a concerning indication of the level of Covid-19 circulating in our communities,” he said. He stressed that vaccines are effective. And while it is possible for fully vaccinated individuals to become infected and pass the virus on to others, the medicine reduces that risk significantly. “That is why it is vital for as many people as possible to come forward for vaccination against this disease,” he said.

https://www.irishtimes.com/news/health/covid-19-additional-2-125-cases-reported-as-hse-urges-vaccinations-1.4653143